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Oxymorphone vs Oxycodone: Opana ER vs Roxicodone

Published: 2026-08-08 · Reviewed by Opioids Pharmacy Editorial Team

Oxymorphone vs Oxycodone is one of the most common comparisons buyers research before choosing a pain medication. This guide breaks down potency, onset, duration, and clinical use so you can tell the options apart — with links to each product listing and authoritative references.

Oxymorphone Vs Oxycodone at a Glance

	Oxymorphone ER	Oxycodone IR
Potency (vs morphine)	~3x oral	~1.5x
Onset	30-60 min	20-30 min
Duration	~12 h (ER)	4-6 h
Half-life	7-9 h	3-4.5 h
Best for	Opioid-tolerant chronic pain	Breakthrough / severe pain

Oxymorphone (Opana ER): Key Facts

Oxymorphone (Opana ER) is about twice the potency of oxycodone; sold as extended-release Opana ER tablets in 20mg and 40mg strengths for opioid-tolerant patients. Buyers looking for oxymorphone 40mg can review the Oxymorphone (Opana ER) product listing for strength, price, and availability.

References for Oxymorphone (Opana ER)

Oxycodone (Roxicodone): Key Facts

Oxycodone (Roxicodone) is roughly 1.5x morphine potency; immediate-release Roxicodone 30mg is widely used for moderate to severe pain. Buyers looking for oxycodone 30mg can review the Oxycodone (Roxicodone) product listing for strength, price, and availability.

References for Oxycodone (Roxicodone)

Verdict: Which Should You Choose?

Oxymorphone ER delivers stronger, longer coverage per milligram and is typically reserved for opioid-tolerant patients. Immediate-release oxycodone offers more flexible dosing for breakthrough pain. Both are Schedule II opioids with significant dependence potential.