Promethazine with Codeine Cough Syrup 32oz
Promethazine with codeine is a prescription cough suppressant combining an antihistamine with an opioid. This 32oz formulation provides relief from persistent cough and upper respiratory symptoms associated with allergies or colds.
Therapeutic Components
Promethazine: A phenothiazine antihistamine that blocks histamine H1 receptors, reducing allergy symptoms, nausea, and sedation. It also possesses antiemetic and sedative properties.
Codeine: An opioid prodrug metabolized to morphine that suppresses cough reflex in the brainstem and provides mild analgesia.
Clinical Indications
This combination treats:
- Unproductive cough from upper respiratory infections
- Allergy-related cough and rhinorrhea
- Cough disrupting sleep or daily activities
- Symptom relief during cold and flu recovery
Not indicated for: productive cough requiring expectoration, asthma, COPD exacerbations, or pneumonia without physician evaluation.
Dosage and Administration
Typical adult dosing: 5-10ml every 4-6 hours as needed. Do not exceed 30ml in 24 hours. Use measuring device for accurate dosing.
Important precautions:
- Causes significant drowsiness-avoid driving and machinery
- Never combine with alcohol, benzodiazepines, or other sedatives
- Not for children under 18 (respiratory depression risk)
- Store securely away from unauthorized users
Side Effects and Warnings
Common: Drowsiness, dizziness, dry mouth, constipation, blurred vision, confusion (especially in elderly).
Serious: Respiratory depression, severe hypotension, neuroleptic malignant syndrome (rare), paradoxical excitation in children.
Drug Interactions
Extremely dangerous with: Alcohol, benzodiazepines (Xanax, Valium), muscle relaxants, sleeping pills, MAO inhibitors, other opioids.
Ordering from Our Pharmacy
Authentic promethazine-codeine syrup in 32oz bottles:
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