Nalbuphine Hydrochloride 20mg/ml Injection
Nalbuphine 20mg/ml is a synthetic opioid analgesic classified as a mixed agonist-antagonist. With potent kappa-opioid receptor agonism and mu-opioid receptor antagonism, nalbuphine provides effective pain relief while offering unique advantages including treatment of opioid-induced pruritus and a superior safety profile compared to full mu-agonists like morphine.
Pharmacological Profile
Nalbuphine’s distinct receptor binding creates unique clinical characteristics:
- Kappa-opioid receptor: Full agonist – produces analgesia and sedation
- Mu-opioid receptor: Competitive antagonist – blocks morphine, fentanyl effects
- Ceiling effect: Respiratory depression plateaus at higher doses – critical safety advantage
Clinical Applications
Primary uses:
- Post-operative analgesia and balanced anesthesia
- Obstetric pain management during labor and delivery
- Acute pain in emergency settings
- Pre-operative and post-operative sedation
Unique indication – Opioid-Induced Pruritus (OIP):
Nalbuphine is specifically effective for severe itching caused by other opioids. Its mu-antagonism blocks the pruritic pathway while maintaining analgesia through kappa-agonism.
Comparative Pharmacology
| Characteristic | Nalbuphine | Butorphanol | Morphine |
|---|---|---|---|
| Potency | 0.8-1.0x morphine | 5-7x morphine | 1x baseline |
| Duration | 3-6 hours | 3-4 hours | 3-4 hours |
| Respiratory ceiling | Yes | Yes | No |
| Schedule | IV | IV | II |
Dosage Guidelines
Standard dosing:
- Initial: 10mg IV, IM, or subcutaneous every 3-6 hours
- May increase to 20mg for severe pain
- Maximum: Generally 160mg/day (ceiling effect provides inherent limitation)
Obstetric dosing: 10-20mg IV or IM during active labor. Preferred over meperidine for less neonatal depression.
Pruritus treatment: 5-10mg IV for severe opioid-induced itching.
Safety Profile
Advantages over morphine:
- Ceiling effect on respiratory depression
- No significant histamine release
- Minimal cardiovascular effects
- Lower abuse potential
- Schedule IV (less restrictive)
Contraindications: Hypersensitivity to nalbuphine, patients dependent on full opioid agonists (precipitates withdrawal), severe respiratory depression not from opioids.
Drug Interactions
Major interactions:
- Full opioid agonists: Antagonizes morphine, fentanyl, oxycodone
- CNS depressants: Additive effects with benzodiazepines (Xanax, Valium, Ativan), alcohol
Warning: Nalbuphine WILL precipitate withdrawal in opioid-dependent patients. Never administer to patients on chronic morphine or oxycodone without ensuring sufficient clearance time.
Side Effects
Common: Sedation, sweating, nausea, headache, dizziness, dry mouth.
Psychotomimetic (less common): Dysphoria, confusion, hallucinations (rare).
Ordering from Our Pharmacy
We provide authentic nalbuphine 20mg/ml injection:
- Pharmaceutical-grade nalbuphine HCl with certificate of analysis
- Sterile parenteral formulation
- Competitive pricing on mixed agonist-antagonist opioids
- Discreet shipping with temperature control
- 24/7 support: +1 951 597 6118 (call/text/WhatsApp)
- Payment: Credit cards, Bitcoin (10% discount), CashApp, Venmo, Zelle, Chime
Appropriate medical documentation required for Schedule IV purchases.
Related Products
Clinical alternatives: Butorphanol (higher potency), Pentazocine, Buprenorphine (longer duration).
Contact
?? Phone/Text/WhatsApp: +1 951 597 6118
?? Email: sales@opioidspharmacy.com
Licensed pharmacy specializing in anesthesia and pain management. DEA-compliant with strict controlled substance protocols.
